From Bowling Green, Kentucky
- Take William H. Natcher Parkway North to toll road (0.2 miles)
- Merge onto Green River Pkwy North (William H Natcher Pkwy) (34 miles)
- At Exit 41B, take ramp onto Wendell H Ford Western Kentucky Pkwy towards Western Kentucky Pkwy West/Paducah (73.3 miles)
- At Exit 4, keep right onto ramp towards US-62/Eddyville (0.4 miles)
- Bear right (West) onto US-62 (3.2 miles)
- Turn left (South-East) onto SR-93 (3 miles)
- Turn right (West) onto SR-730 (2.3 miles)
- Turn right (South-West) onto Water Street
From Frankfort, Kentucky
- Take Hwy 127 South to the Blur Grass Pkwy
- Turn West on to the Blue Grass Pkwy
- Take ramp onto Wendell H Ford Western Kentucky Pkwy towards Western Kentucky Parkway West/Owensboro/Paducah (132.7 miles)
- At the end of the parkway, take the I-24 East/Nashville exit (2.1 miles)
- At exit 45 turn right (West) onto SR-293 (0.4 miles)
- Turn right (North-West) onto SR-93 (0.6 miles)
- Bear left (West) onto SR-730 (2.3 miles)
- Turn right (South-West) onto Water Street
From Louisville, Kentucky
- Take I-65 towards I-65/Nashville (44.1 miles)
- At exit 91, turn right onto ramp towards US-31W/KY-61/Western Kentucky Pkwy/Hodgenville/Paducah (0.3 miles)
- Keep right to stay on ramp towards US-31W/KY-61/Western Kentucky Pkwy/Hodgenville/Paducah (0.2 miles)
- Take ramp onto Wendell H. Ford Western Kentucky Pkwy towards Western Kentucky Pkwy West/Owensboro/Paducah (132.7 miles)
- At the end of the parkway, take the I-24 Nashville exit (2.1 miles)
- At exit 45 turn right (West) onto SR-293 (0.4 miles)
- Turn right (North-West) onto SR-93 (0.6 miles)
- Bear left (West) onto SR-730 (2.3 miles)
- Turn right (South-West) onto Water Street
From Paducah, Kentucky
- Take I-24 East to exit 45 (37.4 miles)
- Turn right onto ramp towards KY-293/Princeton (0.3 miles)
- Take ramp onto SR-293 towards Princeton (0.3 miles)
- Turn right (North-West) onto SR-93 (0.6 miles)
- Bear left (West) onto SR-730 (2.3 miles)
- Turn right (South-West) onto Water Street
From Owensboro, Kentucky
- Take the Pennyrile Parkway South (0.2 miles)
- At exit 63, bear right (South) onto Edward T Breathitt Pennyrile Pkwy (18 miles)
- Road name changes to US-41 (Edward T Breathitt Pennyrile Pkwy) (10.1 miles)
- At exit 34B, take ramp onto Wendell H Ford Western Kentucky Pkwy towards Western Kentucky Pkwy West/Paducah (34.6 miles)
- At exit 4, keep right onto ramp towards US-62/Eddyville (0.4 miles)
- Bear right (West) onto US-62 (3.2 miles)
- Turn left (South-East) onto SR-93 (3.0 miles)
- Turn right (West) onto SR-730 (2.3 miles)
- Turn right (South-West) onto Water Street